The effect of sodium pyruvate is briefly introduced.

Sodium pyruvate is naturally present in the human body and is involved in the metabolism of tissues and organs throughout the body. Is a class of endogenous small molecular substances, in medicine, diagnostic reagents and medical devices are widely used as buffers, excipients and antioxidants.

Purification of sodium pyruvate (if not qualified):

Add: purified water 400 kg, pyruvate 2.5 kg. Open the stirring, open the feed port, slowly add unqualified sodium pyruvate 240 kg to be treated, steam temperature up to 50? 55 ℃, until sodium pyruvate is completely dissolved, slowly add the dissolved sodium pyruvate solution into the filter cylinder, and drain the filtrate into the water separation tank, and the filtration is finished. 1440kg 95% ethanol was pumped into the water separation tank through a filter and cooled to 0? 5 ℃, centrifuged to dry, and sent to the drying room.

Effect of sodium pyruvate(http://www.hnhbsj.com)
antioxidant
The results showed that sodium pyruvate could effectively prevent the glycolysis disorder induced by reactive oxygen radicals in the retina and maintain the normal ratio of NAD / NADH. The results showed that pyruvate could effectively eliminate ROS, and play a significant role in antioxidation in neuropathology. At the same time, oxidative stress can activate PARP-1 and lead to the consumption of NAD in cytoplasm, inhibit glycolysis, and cell death due to lack of energy. Pyruvate can reduce the energy supply of activated PARP-1, to protect nerve cells.

The results show that sodium pyruvate may help to improve and even prevent hemorrhagic shock after hepatocyte dysfunction. Sodium pyruvate can inhibit apoptosis by inhibiting caspase-3 and improving GSH/GSSG ratio. The results showed that exogenous sodium pyruvate could also improve the redox state of cells.

The results showed that sodium pyruvate could eliminate H _ 2O _ 2, decrease the levels of ROS and RNS, and effectively inhibit the damage of DNA under oxidative stress, when exposed to H _ 2O _ 2, which was sensitive to H2O2. The results suggest that pyruvate can be used to remove the damage of hydrogen peroxide and other active compounds.

The results showed that pyruvic acid of 1mM could not only inhibit the increase of H2O2 concentration to kill normal cells, but also inhibit the production of ROS in cells exposed to H2O2. These results showed that pyruvate had the ability to neutralize H2O2. The effect of cell protection can be realized by anti-oxidation.

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